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Medical Biochemistry course 
 Documents 
-Medical Biochemistry course 
 - Unit One: Enzymes 
 -Principles and classifications of Enzymes 
- Mechanism action of Enzymes 
- Enzyme Inhibition 
- Regulation of Enzyme activity 
- Enzymes in clinical diagnosis 
- Unit Two: Carbohydrate Metabolism 
 -Chemistry of Carbohydrates 
- Functions of Carbohydrates 
- Digestion and absorption of Carbohydrates 
- Glycolysis 
- Glycogen Metabolism 
- Glycogen storage diseases 
- Pentose phosphate pathway 
- The Cori - cycle 
- Gluconeogenesis 
- Unit Three: Integrative Metabolism Bioenergetics 
 -Introduction 
- Structural basis of high energy phosphate 
- Formation and utilization of ATP 
- Catabolism of fuel molecules 
- Concept of Free energy 
- Oxidation-reduction reactions 
- Aerobic energy generation 
- Kreb’s cycle 
- Function and regulation of kreb’s cycle 
- Electron transport system and oxidative Phosphorylation 
- Respiratory control 
- Uncouplers 
- Respiratory poisons 
- Unit Four: Lipid Metabolism 
 -Classification of Lipids 
- Types of Lipids 
- Digestion and absorption of Lipids 
- Metabolism of Fatty acids and Triacyl Glycerols 
- β-Oxidation of Fatty acids 
- Metabolism of Ketone bodies 
- Biosynthesis of Fatty acids and triacyl glycerols 
- Cholesterol Metabolism 
- Atherosclerosis 
- Hypercholesterolemic drugs 
- Lipid storage diseases 
- Fatty Liver 
- Lipoproteins 
- Chemical compositions of Membranes 
- Unit Five: Amino acids and Proteins 
 -Classification of amino acids 
- Properties of amino acids 
- Peptides 
- Glutathione synthesis 
- Proteins 
- Classifications of proteins 
- Levels of organization of proteins 
- Denaturation of proteins 
- Hemoglobin and Myoglobin 
- Sickle cell Hemoglobin 
- Sickle cell disease, Sickle cell trait 
- Digestion and absorption of proteins 
- Amino acid catabolism 
- Nitrogen balance, excretion and the urea cycle 
- Defects in the urea cycle 
- The Glucose - Alanine cycle 
- Inborn errors of amino acid metabolism 
- Amino acid derived nitrogenous compounds 
- Clinical problems 
- Unit Six: Vitamins and Coenzymes 
 -Water soluble vitamins 
- Chemistry, sources, function and deficiency of: Thamine 
- Riboflavin 
- Niacin 
- Pyridoxine 
- Biotin 
- Cobalamin 
- Folic acid 
- Panthothenic acid 
-- Ascorbic acid 
- Fat soluble vitamins 
- Chemistry, Sources, function, deficiency and Hypervitaminosis of: Vitamin A 
- Chemistry, Sources, function, deficiency and Hypervitaminosis of: Vitamin D 
-- Chemistry, Sources, function, deficiency and Hypervitaminosis of: Vitamin E 
- Chemistry, Sources, function, deficiency and Hypervitaminosis of: Vitamin K 
- Unit Seven: Miniral Metabolism 
 -Mineral 
- Sodium and potassium 
-Calcium and Phosphate 
- Trace elements 
- Iron 
- Copper 
- Magnesium 
- Flourine 
- Iodine 
- Zinc 
- Selenium 
- Unit Eight: Hormones 
 -Definition and classification OF Hormones 
- Biosynthesis, storage, transport 
- Mechanism of action of steroid hormones 
- Mechanism of action of protein hormones 
- Receptors and diseases 
- Second messengers 
- Insulin synthesis, secretion and metabolic role 
- Diabetes mellitus 
- Symptoms and complications of DM 
- Glucagon 
- Clinical aspects of hormones 
- Thyroxin 
- Synthesis and Metabolism 
-Hypo and Hyper Thyroidism 
- Goiter 
- Catecholamines 
-- Pheochromocytoma 
- Unit Nine: Molecular Genetics 
 -Structure of Nucleic acids 
- Types of Nucleic acids 
- Replication of DNA 
- DNA Damage and repair mechanism 
- RNA synthesis 
- Post transcriptional Modifications 
- Translation/Protein synthesis 
- Regulation of protein synthesis 
- The Genetic code

Medical Biochemistry course

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